If the Di2 rear derailleur of the ST2S or ST5 grinds, creaks, rattles or the chain jumps, it may be due to the setting.
> See 'Di2 rear derailleur adjustment'
Often, however, it is simply due to wear and tear or a lack of maintenance.
> See PROBLEMS - Chain (-pulley) / pulleys and belts
– 'Chain jumps, slips, crunches, is thrown off'
– 'Chainring / bottom bracket - wear and tear?